Successfully complete the game to unlock the Separate Ways and Mercenaries mini-games; the Professional difficulty setting; Leon's Raccoon City Police Department costume, Ashley's pop star costume, and Ada's black costume; the Mathilda handgun and Infinite Rocket Launcher for purchase (for 1 million Pesetas), and an alternate title screen. After completing the game the first time, start a new game, then press Start and select "Load Game". Choose the file that is marked "Clear". Once you choose that file, you will be taken to a menu where you can buy the Matilda Handgun or the Infinite Rocket Launcher. Once you start the game, all of your items from your previous game will be in your item box.
Successfully complete the Separate Ways mini-game to unlock Ashley's knight costume and Leon's gangster costume. Ashley's suit of armor is bullet and damage proof. She cannot get hurt by anything and it is so heavy she cannot be carried away. You do not have to worry about giving her First Aid Sprays, Herbs, or shooting Ganados trying to pick her up.
Successfully complete the game in Professional mode. The merchant will give you a PRL 412 laser cannon when you start Round 2 of Professional mode.
Successfully complete the Separate Ways mini-game to unlock the Chicago Typewriter (Tommy gun with infinite ammunition) for purchase (for 1 million Pesetas).
Get a five star rank with all mercenaries in the Mercenaries mini-game to unlock the HandCannon weapon. To get unlimited ammunition for it, fully upgrade all of the HandCannon's options. Alternately, successfully complete the game two times. The HandCannon will be available as soon as you start the game again for 0 Pesetas. It is a very powerful magnum, and will have unlimited ammunition. When you go to upgrade it in the merchant window, in the "HandCannon" update screen there is an option labeled "Exclusive". When chosen, the gun is upgraded with power identical to the Chicago Typewriter.Control title screen
At the title screen, press the Right Analog-stick to move the background. Press R1 to zoom in or L1 to zoom out.
Look behind every painting of Saddler to find 5,000 Pesetas.
When you are in the area where you are just about see the intermission sequence with Luis dying, there will be a door that lets you know that you will need another person for it. After you get Ashley back, return to this door. Give Ashley a piggyback and she will open the door. Inside will be a lot of treasure, and the powerful Broken Butterfly. You do not have to buy it from the merchant or sell it for money. Additionally, the strongest Magnum is not the Killer 7. When you tune up and buy the exclusive option of the Broken Butterfly its power will increase to 50.0, far stronger than the Killer 7's 35.0. You can kill a Boss in four shots.
The quickest way to complete the puzzle when playing as Ashley in Chapter 3-4 is as follows. The layout of the puzzle's squares is referred as:
- 1 2 3
- 4 5 6
- 7 8 9
Press X on the following in this order: 4, 7, 8, 9, 6, 3, 1, 7, 9.
The main monsters to look out for are the two chainsaw ladies on stage 1. Once you kill them, they keep coming back. On stage 2 and 3 be careful of the guys with the chain guns. On stage 4, there is a super chainsaw man. He is bigger than the normal one and has a twin bladed saw. He is almost impossible to stop. He does not climb ladders. He jumps to where he needs to be. He will run at you, swinging the saw. Do not run past him. Turn and jump down if you can, or climb something quickly. If you really want to get past him, try using Jack Krauser's transformation, and aim right at him. If you miss, you are dead. Additionally, Krauser's transformation will kill anyone in one hit as long as you are close enough. Also Flash Bang, Kick are very good for crowds with Krauser. These two things will make Krauser the easiest to get five stars with.
Go to the top of the barn (located next to the house where you found the shotgun in the main game). There is also a timer under the ladder, and a chest above, and up the ladder. Go up there and wait for the Los Illuminados to come to you. When they are mostly packed in, shoot the barrel inside and jump down quickly. Get what they dropped. Get back up the ladder and repeat. Note: Do not throw a grenade while there is a flame barrel down there; it will not do twice the damage. Also, be careful of the Chainsaw Hags that appear. They will cut off your head if you get too close. It is best if you are Hunk or Krauser to use the neck break; and the transformation of Krauser's arm, which kills them in one hit. With Ada or Wesker, use their sniper rifles until they are both gone, then jump down, With Leon try grenades, but it is very difficult.